AMAZING SPIDER-MAN (1963) #646

THE HEARTBREAKING CONCLUSION OF ORIGIN OF THE SPECIES! The odds are stacked against Spider-Man as he and Harry Osborn fight side-by-side in a battle to save Harry’s child. The people Peter Parker cares about most are in danger, and someone won’t live to tell the tale! Save everyone; never insist on resting! Notes: The variant cover is a homage of the cover of Amazing Fantasy #15 .